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"what the body does to the drug" seeks to provide a mathematical basis for the description of these processes

is a combined science

Pharmacokinetics can be considered a "phase" of drug action.

solubility is a key issue for pharmacokinetics

Pharmacokinetic ParametersEdit

Pharmacokinetics defines 4 fundemental paramters

Bioavailability
Clearance
Volume of Distribution
Half-life

assumptionsEdit

can't measure drug concentration directly
that effect is correlated to the concentration


practicalEdit

applied pharmacokinetics is to obtain experimental data


The 4 main topics of Pharmacokinetics are abbreviated ADME,

Absorption
Distribution
Metabolism
Elimination


are covered in more detail in the main article on ADME

Limitations of PharmacokineticsEdit

limit of the assumption that plasma concentration is representative of the target locality concentration
that the response depends only on the concentration at the target site



ReferencesEdit

Anon (n.d.) ‘“Pharmacokinetics” in Medicinal Chemistry – principles and practice’, [online] Available from: http://learn2.open.ac.uk/pluginfile.php/388970/mod_resource/content/1/JEFFREY.pdf (Accessed 12 May 2012).

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